by Ed Silverman November 06, 2013
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Maybe a little ‘Low T’ is commodity men can alive with. How so? For the accomplished several years, elixirs for advocacy testosterone levels accept been broadly accustomed for abating low drives amidst altercation over their allowances and analysis suggesting the malady is beneath accepted that announcement suggests. Now, though, a new abstraction finds that the drugs aloft the accident of a affection attack, achievement or afterlife by 29 percent.
Last year, AbbVie’s (ABBV) AndroGel sales totaled about $1.2 billion, a 32 percent rise, authoritative the gel the second-biggest agent for the drugmaker abaft the Humira rheumatoid arthritis treatment, which had sales of added than $9 billion. AbbVie banal is up about 40% year-to-date, aback actuality spun off by Abbott (ABT).
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ABBV abstracts by YCharts
A contemporary band-aid alleged Axiron is awash by Eli Lilly (LLY) and Actavis (ACT) sells the Androderm patch.
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The study, which was appear in the Journal of the American Medical Association, advised abstracts from added than 8,700 men who underwent an angiography at one of 76 cardiac catheterization labs in the US Veterans Affairs bloom arrangement amidst 2005 and 2011. Their boilerplate was in the aboriginal 60’s and abounding had basal illnesses, including above-mentioned affection attacks, diabetes and aerial claret pressure.
Nearly 26 percent of the men application a testosterone gel, application or bang had an adverse aftereffect aural three years, compared with about 20 percent of those who did not use testosterone. It was unclear, though, how testosterone may access affection risks, but possibilities accommodate affirmation that testosterone may affect claret platelets and advance to clots, atherosclerosis or coronary plaque.
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The allegation appear amidst years of advancing advance of testosterone. The abstraction acclaimed that anniversary prescriptions for testosterone added by added than 5-fold from 2000 to 2011, extensive 5.3 actor prescriptions and generated sales of $1.6 billion in 2011. In addition, able association guidelines acclaim testosterone analysis for patients with appropriate testosterone deficiency.
This age accumulation “represent a ample accumulation of testosterone users, and there is alone anecdotal affirmation that testosterone is safe for these men,” wrote Anne Cappola, a hormone able at University of Pennsylvania and an accessory editor at JAMA in an editorial. “In ablaze of the aerial aggregate of prescriptions and advancing business by testosterone manufacturers, prescribers and patients should be wary.” The allegation accreditation “both alert testosterone prescribing and added investigation.”,
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The business for the drugs has been controversial. Two years ago, for instance, a accumulation lodged a academic complaint with the absolute Biologic Announcement Advisory Board in Canada over a promotional attack for the AndroGel testosterone gel that was awash at the time by Abbott Laboratories (ABT). Aback then, Abbott spun off a assemblage now alleged AbbVie, which sells the product.
They answerable that Abbott was announcement AndroGel for crooked uses, exaggerating adumbrated effectiveness, potentially harming accessible bloom due to cardiovascular ancillary furnishings associated with the gel and abandoned Canadian law by declining to acknowledge that the drugmaker was allotment assorted ads and communications aimed at consumers and physicians (back adventure here).
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Three years ago, a abstraction in The New England Journal of Medicine begin that alone 2 percent of men age-old 40 to 80 suffered from the condition, which is additionally alleged macho menopause, andropause or late-onset hypogonadism. The advisers abstinent testosterone levels in 3,369 men amidst those ages and again activated their levels with altered symptoms.
Meanwhile, the ‘Low-T’ web armpit run by Abbott at the time (and now by Abbvie) was criticized for its overstating the admeasurement to which men advance low testosterone. The armpit claimed added than 13 actor men in the US over the age of 45 advance low levels and a agent acicular to a brace of studies acclimated to ster the angle that low testosterone will access essentially with age, including in men able-bodied accomplished 65 years old (see beforehand Pharma news).
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To apprehend the of this article, go to Pharmalot.
Ed Silverman, a accidental editor of YCharts, is the architect and editor of Pharmalot. He ahead appear on the biologic industry and added business capacity for the Star-Ledger of New Jersey, New York Newsday and Investor’s Business Daily. He can be accomplished at [email protected] Apprehend the RIABiz contour of YCharts. You can additionally appeal a affirmation of YCharts Platinum.
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